Virus-Related Publications

Sidney Altman

• Yang, L., Wesolowski, D., Li, Y., and Altman, S. (2005) Analysis of putative RNase P RNA from orthopoxviruses. J. Mol. Biol. 354:529-535.

Karen Anderson

• Basavapathruni, A., Vingerhoets, J., de Bethune, M.P., Chung, R., Bailey, C.M., Kim, J., and Anderson, K.S. (2006) Modulation of human immunodeficiency virus type 1 synergistic inhibition by reverse transcriptase mutations. Biochemistry 45:7334-7340.
• Basavapathruni, A. and Anderson, K.S. (2006) Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly. Curr. Pharm. Des. 12:1857-1865.
• Ruiz-Caro, J., Basavapathruni, A., Kim, J.T., Bailey, C.M., Wang, L., Anderson, K.S., Hamilton, A.D., and Jorgensen, W.L. (2006) Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. Med. Chem. Lett. 16:668-671.
• Jorgensen, W.L., Ruiz-Caro, J., Tirado-Rives, J., Basavapathruni, A., Anderson, K.S., and Hamilton, A.D. (2006) Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. Med. Chem. Lett. 16:663-667.
• Ray, A.S., Hernandez-Santiago, B.I., Mathew, J.S., Murakami, E., Bozeman, C., Xie, N.Y., Dutschman, G.E., Gullen, E., Yang, Z., Hurwitz, S., Cheng, Y.C., Chu, C.K., McClure, H., Schinazi, R.F., and Anderson, K.S. (2005) Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2’,3’-didehydro-2’,3’-dideoxyguanosine. Antimicrob. Agents Chemother. 49:1994-2001.

Warren Andiman

• Alexander, L., Cuchura, L., Simpson, B.J., and Andiman, W.A. (2006) Virologic and host characteristics of human immunodeficiency virus type 1-infected pediatric long term survivors. Pediatr. Infect. Dis. J. 25:135-141.

Janet Brandsma

• Brandsma, J.L. (2005) The cottontail rabbit papillomavirus model of high-risk HPV-induced disease. Methods Mol. Med. 119:217-235.
• Du, M., Fan, X., Hanada, T., Gao, H., Lutchman, M., Brandsma, J.L., Chishti, A.H., and Chen, J.J. (2005) Association of cottontail rabbit papillomavirus E6 oncoproteins with the hDlg/SAP97 tumor suppressor. J. Cell Biochem. 94:1038-1045.
• Peh, W.L., Brandsma, J.L., Christensen, N.D., Cladel, N.M., Wu, X., and Doorbar, J. (2004) The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo. J. Virol. 78:2142-2151.
• Brandsma, J.L., Shlyankevich, M., Zhang, L., Slade, M.D., Goodwin, E.C., Peh, W., and Deisseroth, A.B. (2004) Vaccination of rabbits with an adenovirus vector expressing the papillomavirus E2 protein leads to clearance of papillomas and infection. J. Virol. 78:116-123.

Yung-Chi Cheng

• Qin, X., Che, X., Wang, K., Polin, L., Kern, E.R., Drach, J.C., Gullen, E., Cheng, Y.C., and Zemlicka, J. (2006) Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides. Bioorg. Med. Chem. 14:1247-1254.
• Cheng, Y.C., Ying, C.X., Leung, C.H., and Li, Y. (2005) New targets and inhibitors of HBV replication to combat drug resistance. J. Clin. Virol. 34S:S147-150.
• Ambrose, A., Zemlicka, J., Kern, E.R., Drach, J.C., Gullen, E., and Cheng, Y.C. (2005) Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity. Nucleosides Nucleotides Nucl. Acids 24:1763-1774.
• Haraguchi, K., Takeda, S., Sumino, M., Tanaka, H., Dutschman, G.E., Cheng, Y.C., Nitanda, T., and Baba, M. (2005) A new approach to the synthesis of 4’-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2’,3’-didehydro-3’-deoxy-4’-ethynylthymidine. Nucleosides Nucleotides Nucl. Acids 24:343-347.
• Tanaka, H., Haraguchi, K., Kumamoto, H., Baba, M., and Cheng, Y.C. (2005) 4’-Ethynylstavudine (4’-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants. Antivir. Chem. Chemother. 16:217-221.
• Nitanda, T., Wang, X., Kumamoto, H., Haraguchi, K., Tanaka, H., Cheng, Y.C., and Baba, M. (2005) Anti-human immunodeficiency virus type 1 activity and resistance profile of 2’,3’-didehydro-3’-deoxy-4’-ethynylthymidine in vitro. Antimicrob. Agents Chemother. 49:3355-3360.

Susan Compton

• Compton, S.R., Ball-Goodrich, L.J., Johnson, L.K., Johnson, E.A., Paturzo, F.X., and Macy, J.D. (2004) Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comp. Med. 54:681-689.
• Compton, S.R., Jacoby, R.O., Paturzo, F.X., and Smith, A.L. (2004) Persistent Seoul virus infection in Lewis rats. Arch. Virol. 149:1325-1339.
• Compton, S.R., Ball-Goodrich, L.J., Paturzo, F.X., and Macy, J.D. (2004) Transmission of enterotropic mouse hepatitis virus from immunocompetent and immunodeficient mice. Comp. Med. 54:29-35.
• Compton, S.R., Ball-Goodrich, L.J., Zeiss, C.J., Johnson, L.K., Johnson, E.A., and Macy, J.D. (2003) Pathogenesis of mouse hepatitis virus infection in gamma interferon-deficient mice is modulated by co-infection with Helicobacter hepaticus. Comp. Med. 53:197-206.

Peter Cresswell

• Peaper, D.R., Wearsch, P.A., and Cresswell, P. (2005) Tapasin and Erp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex. EMBO J. 24:3613-3623.
• Modiano, N., Lu, Y.E., and Cresswell, P. (2005) Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor. Proc. Natl. Acad. Sci. USA 102:8680-8685.
• Ackerman, A.L., Kyritsis, C., Tampe, R., and Cresswell, P. (2005) Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells. Nat. Immunol. 6:107-113.

Daniel DiMaio

• Nguyen, M., Kraft, R.M., Aubert, M., Goodwin, E.C., DiMaio, D., and Blaho, J. (2007) p53 and hTERT determine sensitivity to viral apoptosis. J. Virol. 81:12985-12995.
• Psyrri, D. and DiMaio, D. (2007) Papillomaviruses in cervical and head and neck carcinoma. Nat. Clin. Pract. Oncol. (In press).
• Horner, S.M. and DiMaio, D. (2007) The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. J. Virol. 81:6254-6264.
• Ptacek, J.B., Edwards, A.P.B., Freeman-Cook, L.L., and DiMaio, D. (2007) Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGF beta receptor.  Proc. Natl. Acad. Sci. USA 104:11945-11950.

• Johung, K., Goodwin, E.C., and DiMaio, D. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J. Virol. 81:2102–2116.
• Book:  Papillomaviruses. (2007) Garcea, R. and DiMaio, D., eds., 430 pp. Springer.

Savithramma Dinesh-Kumar

• Marathe, R., Guan, Z., Anandalakshmi, R., Zhao, H., and Dinesh-Kumar, S.P. (2004) Study of Arabidopsis thaliana resistome in response to cucumber mosaic virus infection using whole genome microarray. Plant Mol. Biol. 55:501-520.
• Liu, Y., Schiff, M., and Dinesh-Kumar, S.P. (2004) Involvement of MEK1 MAPKK, NTF6 MAPK, WRKY/MYB transcription factors, COI1 and CTR1 in N-mediated resistance to tobacco mosaic virus. Plant J. 38:800-809.
• Liu, Y., Burch-Smith, T., Schiff, M., Feng, S., and Dinesh-Kumar, S.P. (2004) Molecular chaperone Hsp90 associates with resistance protein N and its signaling proteins SGT1 and Rar1 to modulate an innate immune response in plants. J. Biol. Chem. 279:2101-2108.

Erol Fikrig

• Wang, T., Gao, Y., Scully, E., Davis, C.T., Anderson, J.F., Welte, T., Ledizet, M., Koski, R., Madri, J.A., Barrett, A., Yin, Z., Craft, J., and Fikrig, E. (2006) gλ-T cells facilitate adaptive immunity against West Nile virus infection in mice. J. Immunol. 177:1825-1832.
• Shrestha, B., Wang, T., Samuel, M.A., Whitby, K., Craft, J., Fikrig, E., and Diamond, M.S. (2006) Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J. Virol. 80:5338-5348.
• Ledizet, M., Kar, K., Foellmer, H.G., Wang, T., Bushmich, S.L., Anderson, J.F., Fikrig, E., and Koski, R.A. (2005) A recombinant envelope protein vaccine against West Nile virus. Vaccine 23:3915-3924.
• Kanai, R., Kar, K., Anthony, K., Gould, L.H., Ledizet, M., Fikrig, E., Marasco, W.A., Koski, R.A., and Modis, Y. (2006) Crystal structure of West Nile virus envelope glycoprotein reveals viral surface epitopes. J. Virol. 80:11000-11008.
• Bai, F., Town, T., Pradhan, D., Cox, J., Ashish, B., Ledizet, M., Anderson, J.F., Flavell, R.A., Krueger, J.K., Koski, R.A., and Fikrig, E. (2007) Antiviral peptides targeting the West Nile virus envelope protein. J. Virol. 81:2047-2055.
• Wang, T., Gao, Y., Scully, E., Davis, C.T., Anderson, J.F., Welte, T., Ledizet, M., Koski, R., Madri, J.A., Barrett, A., Yin, Z., Craft, J., and Fikrig, E. (2006) Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. J. Immunol. 177:1825-1832.

Durland Fish

• Spielman, A., Andreadis, T.G., Apperson, C.S., Cornel, A.J., Day, J.F., Edman, J.D., Fish, D., Harrington, L.C., Kiszewski, A.E., Lampman, R., Lanzaro, G.C., Matuschka, F.R., Munstermann, L.E., Nasci, R.S., Norris, D.E., Novak, R.J., Pollack, R.J., Reisen, W.K., Reiter, P., Savage, H.M., Tabachnikc, W.J., and Wesson, D.M. (2004) Outbreak of West Nile virus in North America. Science 306:1473-1475.

Frank Giordano

• Yu, J., Lei, L., Liang, Y., Hinh, L., Hickey, R.P., Huang, Y., Liu, D., Yeh, J.L., Rebar, E., Case, C., Spratt, K., Sessa, W.C., and Giordano, F.J. (2006) An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice. FASEB J. 20:479-481.
• Tang, N., Wang, L., Esko, J., Giordano, F.J., Huang, Y., Gerber, H.P., Ferrara, N., and Johnson, R.S. (2004) Loss of HIV-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6:485-495.
• Gratton, J.P., Yu, J., Griffith, J.W., Babbitt, R.W., Scotland, R.S., Hickey, R., Giordano, F.J., and Sessa, W.C. (2003) Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat. Med. 9:357-362. (Erratum: Nat. Med. 9:1221.)

Peter Glazer

• Knauert, M.P., Kalish, J.M., Hegan, D.C., and Glazer, P.M. (2006) Triplex-stimulated intermolecular recombination at a single-copy genomic target. Mol. Ther. 14:392-400.
• Shahid, K.A., Majumdar, A, Alam, R., Liu, S.T., Kuan, J.Y., Sui, X., Cuenoud, B., Glazer, P.M., Miller, P.S., and Seidman, M.M. (2006) Targeted cross-linking of the human b-globin gene in living cells mediated by a triple helix forming oligonucleotide. Biochemistry 45:1970-1978.
• Kim, K.H., Nielsen, P.E., and Glazer, P.M. (2006) Site-specific gene modification by PNAs conjugated to psoralen. Biochemistry 45:314-323.
• Kalish, J.M. and Glazer, P.M. (2005) Targeted genome modification via triple helix formation. Ann. N.Y. Acad. Sci. 1058:151-161.
• Rogers, F.A., Lloyd, J.A., and Glazer, P.M. (2005) Triplex-forming oligonucleotides as potential tools for modulation of gene expression. Curr. Med. Chem. Anticancer Agents 5:319-326.
• Kalish, J.M., Seidman, M.M., Weeks, D.L., and Glazer, P.M. (2005) Triplex-induced recombination and repair in the pyrimidine motif. Nucl. Acids. Res. 33:3492-3502.

Martha Harding

• Wilson, J.H., Paturzo, F.X., Johnson, L.K., Carreiro, M.P., Hixson, D.C., Boyer, J.L., Pober, J.S., and Harding, M.J. (2006) Rat hepatocyte engraftment in severe combined immunodeficient x beige mice using mouse-specific anti-fas antibody. Xenotransplantation 13:53-62.
• Harding, M.J., Cao, X., Shams, H., Johnson, A.F., Vassilev, V.B., Gil, L.H., Wheeler, D.W., Haines, D., Siert, G.J., Nelson, L.D., Campos, M., and Donis, R.O. (2002) Role of bovine viral diarrhea virus biotype in the establishment of fetal infections. Am. J. Vet. Res. 63:1455-1463.

Robert Heimer

• Shaboltas, A.V., Toussova, O.V., Hoffman, I.F., Heimer, R., Verevochkin, S.V., Ryder, R.W., Khoshnood, K., Perdue, T., Masse, B.R., and Kozlov, A.P. (2006) HIV prevalence, sociodemographic, and behavioral correlates and recruitment methods among injection drug users in St. Petersburg, Russia. J. Acquir. Immune Defic. Syndr. 41:657-663.
• Uuskula, A., Heimer, R., Dehovitz, J., Fischer, K., and McNutt, L.A. (2005) Surveillance of HIV, hepatitis B virus, and hepatitis C virus in an Estonian injection drug-using population: sensitivity and specificity of testing syringes for public health surveillance. J. Infect. Dis. 193:455-457.
• Abdala, N., Crowe, M., Tolstov, Y., and Heimer, R. (2004) Survival of human immunodeficiency virus type 1 after rinsing injection syringes with different cleaning solutions. Subst. Use Misuse 39:581-600.
• Schmid, G.P., Buve, A., Mugyenyi, P., Garnett, G.P., Hayes, R.J., Williams, B.G., Calleja, J.G., De Cock, K.M., Whitworth, J.A., Kapiga, S.H., Ghys, P.D., Hankins, C., Zaba, B., Heimer, R., and Boerma, J.T. (2004) Transmission of HIV-1 infection in sub-Saharan Africa and effect of elimination of unsafe injections. Lancet 363:482-488.

Akiko Iwasaki

• Iwasaki, A. (2007) Mucosal dendritic cells. Annu. Rev. Immunol. 25:381-418.
• Lee, H.K., Lund, J.M., Ramanathan, B., Mizushima, N., and Iwasaki, A. (2007) Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315:1398-1401.
• Lund, J.M., Linehan, M.M., Iijima, N., and Iwasaki, A. (2006) Cutting edge: plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. .J. Immunol. 177:7510-7514.
• Sato, A., Linehan, M.M., and Iwasaki, A. (2006) Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc. Natl. Acad. Sci. USA 103:17343-17348.
• Iwasaki, A. (2006) The use of bone marrow-chimeric mice in elucidating immune mechanisms. Book chapter in: Methods in Molecular Medicine 127:281-292.
• Shen, H. and Iwasaki, A. (2006) A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J. Clin. Invest. 116:2237-2243.

Susan Kaech

• Joshi, N.S., Cui, W., Chandele, A., Lee, H.K., Urso, D.R., Hagman, J., Gapin, L., and Kaech, S.M. (2007) Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27:281-295.
• Kaech, S.M. and Wherry, E.J. (2007) Heterogeneity and cell fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity (In Press).
• Hand, T.W., Morre, M., and Kaech, S.M. (2007) Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc. Natl. Acad. Sci. USA 104:11730-11735.
• Chandele, A. and Kaech, S.M. (2005) Memory CD8 T cell maturation occurs independently of CD8alphaalpha. J. Immunol. 175:5619-5623.
• Kaech, S.M., Tan, J.T., Wherry, E.J., Konieczny, B.T., Surh, C.D., and Ahmed, R. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4:1191-1198.
• Kaech, S.M., Hemby, S., Kersh, E., and Ahmed, R. (2002) Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111:837-851.
• Kaech, S.M. and Ahmed, R. (2001) Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells.Nat. Immunol. 2:415-422.

Jeffrey Kahn

• Kahn, J.S. (2006) Epidemiology of human metapneumovirus. Clin. Microbiol. Rev. 19:546-557.
• Esper, F., Weibel, C., Ferguson, D., Landry, M.L., and Kahn, J.S. (2006) Coronavirus HKU1 infection in the United States. Emerg. Infect. Dis. 12:775-779.
• Kahn, J.S. (2006) The widening scope of coronaviruses. Curr. Opin. Pediatr. 18:42-47.
• Martinello, R.A., Esper, F., Weibel, C., Ferguson, D., Landry, M.L., and Kahn, J.S. (2006) Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. J. Infect. (Epub ahead of print).
• Kahn, J.S. and McIntosh, K. (2005) History and recent advances in coronavirus discovery. Pediatr. Infect. Dis. J. 24S:S223-227.
• Leung, J., Esper, F., Weibel, C., and Kahn, J.S. (2005) Seroepidemiology of human metapneumovirus (hMPV) on the basis of a novel enzyme-linked immunosorbent assay utilizing hMPV fusion protein expressed in recombinant vesicular stomatitis virus. J. Clin. Microbiol. 43:1213-1219.

Michael Kozal

• Kozal, M.J., Hullsiek, K.H., Leduc, R., Novak, R.M., MacArthur, R.D., Lawrence, J., Baxter, J.D., and Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). (2006) Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naïve and treatment-experienced patients. Antivir. Ther. 11:457-463.
• Lataillade, M. and Kozal, M.J. (2006) The hunt for HIV-1 integrase inhibitors. (2006) AIDS Patient Care STDS 20:489-501.Kozal, M.J., Amico, K.R., Chiarella, J., Cornman, D., Fisher, W., Fisher, J., and Friedland, G. (2005) HIV drug resistance and HIV transmission risk behaviors among active injection drug users. J. Acquir. Immune Defic. Syndr. 40:106-109.
• Kozal, M.J., Amico, K.R., Chiarella, J., Schreibman, T., Cornman, D., Fisher, W., Fisher, J., and Friedland, G. (2004) Antiretroviral resistance and high-risk transmission behavior among HIV-positive patients in clinical care. AIDS18:2185-2189.
• Kozal, M. (2004) Cross-resistance patterns among HIV protease inhibitors. AIDS Patient Care STDS 18:199-208.

Gary Kupfer

• Haoudi, A., Daniels, R.C., Wong, E., Kupfer, G., and Semmes, O.J. (2003) Human T-cell leukemia virus-1 tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response. J. Biol. Chem. 278:37736-37744.

Marie Landry

• Esper, F., Weibel, C., Ferguson, D., Landry, M.L., and Kahn, J.S. (2006) Coronavirus HKU1 infection in the United States. Emerg. Infect. Dis. 12:775-779.
• Martinello, R.A., Esper, F., Weibel, C., Ferguson, D., Landry, M.L., and Kahn, J.S. (2006) Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. J. Infect. (E-pub).
• Landry, M.L., Garner, R., and Ferguson, D. (2005) Real-time nucleic acid sequence-based amplification using molecular beacons for detection of enterovirus RNA in clinical specimens. J. Clin. Microbiol. 43:3136-3139.
• Landry, M.L., Mullangi, P., Nee, P., and Klein, B.R. (2005) Herpes simplex virus type 2 acute retinal necrosis 9 years after neonatal herpes. J. Pediatr. 146:836-838.

Brett Lindenbach

• von Hahn, T., Lindenbach, B.D., Boullier, A., Quehenberger, O., Paulson, M., Rice, C.M., and McKeating, J.A. (2006) Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. Hepatology 43:932-942.
• Lindenbach, B.D., Meuleman, P., Ploss, A., Vanwolleghem, T., Syder, A.J., McKeating, J.A., Lanford, R.E., Feinstone, S.M., Major, M.E., Leroux-Roels, G., and Rice, C.M. (2006) Cell culture-grown hepatitis C virus in infectious in vivo and can be recultured in vitro. Proc. Natl. Acad. Sci. USA 103:3805-3809.
• Tscherne, D.M., Jones, C.T., Evans, M.J., Lindenbach, B.D., McKeating, J.A., and Rice, C.M. (2006) Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry. J. Virol. 80:1734-1741.
• Lindenbach, B.D. and Rice, C.M. (2005) Unravelling hepatitis C virus replication from genome to function. Nature 436:933-938.
• Lindenbach, B.D., Evans, M.J., Syder, A.J., Wolk, B., Tellinghuisen, T.L., Liu, C.C., Maruyama, T., Hynes, R.O., Burton, D.R., McKeating, J.A., and Rice, C.M. (2005) Complete replication of hepatitis C virus in cell culture. Science 309:623-626.
• Pfeffer, S., Sewer, A., Lagos-Quintana, M., Sheridan, R., Sander, C., Grasser, F.A., van Dyk, L.F., Ho, C.K., Shuman, S., Chien, M., Russo, J.J., Ju, J., Randall, G., Lindenbach, B.D., Rice, C.M., Simon, V., Ho, D.D., Zavolan, M., and Tuschi, T. (2005) Identification of microRNAs of the herpesvirus family. Nat. Methods 2:269-276.

Laura Manuelidis

• Manuelidis L, Yu ZX, Banquero N, Mullins B. (2007) Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles. Proc Natl Acad Sci U S A. 104: 1965-70.
• Nishida, N., Katamine, S., and Manuelidis, L. (2005) Reciprocal interference between specific CJD and scrapie agents in neural cell cultures. Science 310:493-496.
• Lu, Z.Y., Baker, C.A., and Manuelidis, L. (2004) New molecular markers of early and progressive CJD brain infection. J. Cell Biochem. 93:644-652.
• Arjona, A., Simarro, L., Islinger, F., Nishida, N., and Manuelidis, L. (2004) Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures. Proc. Natl. Acad. Sci. USA 101:8768-8773.
• Baker, C.A, Lu, Z.Y., and Manuelidis, L. (2004) Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease.J. Neuroviral. 10:29-40.

Richard Martinello

• Martinello, R.A., Esper, F., Weibel, C., Ferguson, D., Landry, M.L., and Kahn, J.S. (2006) Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. J. Infect. (E-pub).

Robert Means

• Mansouri, M., Douglas, J., Rose, P.P., Gouveia, K., Thomas, G., Means, R.E., Moses, A.V., and Fruh, K. (2006) Kaposi’s sarcoma herpesvirus K5 eliminates CD31/PECAM from endothelial cells. Blood 108:1932-1940.
• Chang, H., Gwack, Y., Kingston, D., Souvlis, J., Liang, X., Means, R.E., Cesarman, E., Hutt-Fletcher, L., Jung, J.U. (2005) Activation of CD21 and CD23 gene expression by Kaposi’s sarcoma-associated herpesvirus RTA. J. Virol. 79:4651-4663.
• Liang, X., Shin, YU.C., Means, R.E., and Jung, J.U. (2004) Inhibition of interferon-mediated antiviral activity by murine g-herpesvirus 68 latency-associated M2 protein. J. Virol. 78:12416-12427.

Ruslan Medzhitov

• Stetson, D.B. and Medzhitov, R. (2006) Antiviral defense: interferons and beyond. J. Exp. Med. 203:1837-1841. Erratum in: J. Exp. Med. 203:2215.
• Kagan, J.C. and Medzhitov, R. (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.Cell 125:943-955.
• Czopik, A.K., Bynoe, M.S., Palm, N., Raine, C.S., and Medzhitov, R. (2006) Semaphorin 7A is a negative regulator of T cell responses. Immunity 24:591-600.
• Barton, G.M., Kagan, J.C., and Medzhitov, R. (2006) Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7:49-56.
• van Duin, D., Medzhitov, R., and Shaw, A.C. (2006) Triggering TLR signaling in vaccination. Trends Immunol. 27:49-55.
• Qureshi, S.T., Zhang, X., Aberg, E., Bousette, N., Giaid, A., Shan, P., Medzhitov, R.M., and Lee, P.J. (2006) Inducible activation of TLR4 confers resistance to hyperoxia-induced pulmonary apoptosis. J. Immunol. 176:4950-4958.

I. George Miller

• El-Guindy, A., Paek, S.Y., Countryman, J., and Miller, G. (2006) Identification of constitutive phosphorylation sites on the Epstein-Barr virus ZEBRA protein. J. Biol. Chem. 281:3085-3095.
• Heston, L., El-Guindy, A., Countryman, J., Dela Cruz, C., Delecluse, H.-J., and Miller, G. (2006) Amino acids in the basic domain of Epstein-Barr virus ZEBRA protein play distinct roles in DNA binding, activation of early lytic gene expression and promotion of viral DNA replication. J. Virol. 80:9115-9133.
• Miller, G. (2007) Lytic cycle switches of oncogenic human gammaherpesviruses. Adv. Cancer Res. (In press).
• Bhaduri-McIntosh, S. and Miller, G. (2006) Cells lytically infected with Epstein-Barr virus are detected and separable by immunoglobulins from EBV-seropositive individuals. J. Virological Meth. 137:103-114.
• Chen, L.-W., Chang, P.-J., Delecluse, H.-J., and Miller, G. (2005) Marked variation in response of consensus binding elements for the Rta protein of Epstein-Barr virus. J. Virol. 79:9635-9650.
• Chang, P.-J., Shedd, D., and Miller, G. (2005) Two subclasses of Kaposi’s sarcoma-associated herpesvirus lytic cycle promoters distinguished by mutants of ORF50 protein deficient in binding. J. Virol. 79:8750-8763.

Yorgo Modis

• Modis, Y., Ogata, S., Clements, D., and Harrison, S.C. (2005) Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J. Virol. 79:1223-1231.
• Modis, Y., Ogata, S., Clements, D., and Harrison, S.C. (2004) Structure of the dengue virus envelope protein after membrane fusion. Nature 427:313-319.
• Kanai, R., Kar, K., Anthony, K., Gould, L.H., Ledizet, M., Fikrig, E., Marasco, W.A., Koski, R.A., and Modis, Y. (2006) Crystal structure of West Nile virus envelope glycoprotein reveals viral surface epitopes. J. Virol. 80:11000-11008.

Walther Mothes

• Lehmann, M.J., Sherer, N.M., Marks, C.B., Pypaert, M., and Mothes, W. (2005) Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J. Cell Biol. 170:317-325.
• Uchil, P. and Mothes, W. (2005) Viral entry: a detour through multivesicular bodies. Nat. Cell Biol. 7:641-642.
• Melikyan, G.B., Barnard, R.J., Abrahamyan, L.G., Mothes, W., and Young, J.A. (2005) Imaging individual retroviral fusion events: from hemifusion to pore formation and growth. Proc. Natl. Acad. Sci. USA 102:8728-8733.
• Smith, J.G., Mothes, W., Blacklow, S.C., and Cuningham, J.M. (2004) The mature avian leucosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J. Virol. 78:1403-1410.

Amanda Psyrri

• Weinberger, P.M., Yu, Z., Haffty, B.G., Kowalski, D., Harigopal, M., Brandsma, J., Sasaki, C., Joe, J., Camp, R.L., Rimm, D.L., and Psyrri, A. (2006) Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis. J. Clin. Oncol. 24:736-747.
• Psyrri, D., DeFilippis, R.A., Edwards, A.P.B., Yates, K.E., Manuelidis, L., and DiMaio, D. (2004) Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res. 64:3079-3086.

Anna Marie Pyle

• Beran, R.K., Bruno, M.M., Bowers, H.A., Jankowsky, E., and Pyle, A.M. (2006) Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track. J. Mol. Biol. 358:974-982.
• Dumont, S., Cheng, W., Serebrov, V., Beran, R.K., Tinoco, I., Jr., Pyle, A.M., and Bustamante, C. (2006) RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature 439:105-108.
• Serebrov, V. and Pyle, A.M. (2004) Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase. Nature 430:476-480.
• Kawaoka, J. and Pyle, A.M. (2005) Choosing between DNA and RNA: the polymer specificity of RNA helicase NPH-II. Nucl. Acids Res. 33:644-649.
• Kawaoka, J., Jankowsky, E., and Pyle, A.M. (2004) Backbone tracking by the SF2 helicase NPH-II. Nat. Struct. Mol. Biol. 11:526-530.

Michael Robek

• Publicover, J., Ramsburg, E., Robek, M., and Rose, J.K. (2006) Rapid pathogenesis induced by a vesicular stomatitis virus matrix protein mutant: viral pathogenesis is linked to induction of tumor necrosis fator alpha. J. Virol. 80:7028-7036.
• Ramsburg, E., Publicover, J., Buonocore, L., Poholek, A., Robek, M., Palin, A., and Rose, J.K. (2005) A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cellresponses and is highly attenuated for replication in animals. J. Virol. 79:15043-15053.
• Isogawa, M., Robek, M.D., Furuichi, Y., and Chisari, F.V. (2005) Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J. Virol. 79:7269-7272.
• Robek, M.D., Boyd, B.S., and Chisari, F.V. (2005) Lambda interferon inhibits hepatitis B and C virus replication. J. Virol. 79:3851-3854.
• Robek, M.D., Boyd, B.S., Wieland, S.F., and Chisari, F.V. (2004) Signal transduction pathways that inhibit hepatitis B virus replication. Proc. Natl. Acad. Sci. USA 101:1743-1747.

John Rose

• Publicover, J., Ramsburg, E., Robek, M., and Rose, J.K. (2006) Rapid pathogenesis induced by a vesicular stomatitis virus matrix protein mutant: viral pathogenesis is linked to induction of tumor necrosis factor alpha. J. Virol. 80:7028-7036.
• Kapadia, S.U., Rose, J.K., Lamirande, E., Vogel, L, Subbarao, K, and Roberts, A. (2005) Long-term protection from SARS coronavirus infection conferred by a single immunization with an attenuated VSV-based vaccine. Virology 340:174-82.
• Ramsburg, E., Publicover, J., Buonocore, L., Poholek, A., Robek, M., Palin, A., and Rose, J.K. (2005) A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cell responses and is highly attenuated for replication in animals. J. Virol. 79:15043-15053.
• Ramsburg, E., Rose, N.F., Marx, P.A, Mefford, M., Nixon, D.F., Moretto, W.J., Montefiori, D., Earl, P.A., Moss, B., and Rose, J.K. (2004) Highly effective control of an AIDS virus challenge in macaques using VSV and MVA vectors in a single-boost protocol. J. Virol. 78:3196-3199.
• Publicover, J., Ramsburg, E., and Rose, J.K. (2004) A single-cycle vaccine vector based on vesicular stomatitis virus can induce immune responses comparable to those generated by a replication-competent vector. J. Virol. 79:13231-8
• Roberts, A., Reuter, J.D., Wilson, J.H., Baldwin, S., and Rose, J.K. (2004) Complete protection from papillomavirus challenge after a single vaccination with a vesicular stomatitis virus vector expressing high levels of L1 protein. J. Virol. 78:3196-3199.

Alanna Schepartz

• Stephens, O.M., Kim, S., Welch, B.D., Hodsdon, M.E., Kay, M.S., and Schepartz, A. (2005) Inhibiting HIV fusion with a beta-peptide foldamer. J. Am. Chem. Soc. 127:13126-13127.
• Kritzer, J.A., Stephens, O.M., Guarracino, D.A., Reznik, S.K., and Schepartz, A. (2005) beta-Peptides as inhibitors of protein-protein interactions. Bioorg Med Chem. 13:11-6.
• Schneider, T.L. and Schepartz, A. (2001) Hepatitis B virus protein pX enhances the monomer assembly pathway of bZIP.DNA complexes. Biochemistry 40:2835-2843.
• Pflum, M.K., Schneider, T.L., Hall, D., and Schepartz, A. (2001) Hepatitis B virus X protein activates transcription by bypassing CREB phosphorylation, not by stabilizing bZIP-DNA complexes. Biochemistry 40:693-703.

Joan Steitz

• Conrad, N.K., Shu, M.-D., Uyhazi, K.E., and Steitz, J.A. (2007) Mutational analysis of a viral RNA element that counteracts rapid RNA decay by interaction with the polyadenylation tail. Proc. Natl. Acad. Sci. USA 104:10412-10417.
• Conrad, N.K., Mili, S., Marshall, E.L., Shu, M.-D., and Steitz, J.A. (2006) Identification of a rapid mammalian deadenylation-dependent decay pathway and its inhibition by a viral RNA element. Molec. Cell 24:943-953.
• Fok, V., Friend, K., and Steitz, J.A. (2006) Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling. J. Cell Biol. 173:319-325.
• Fok, V., Mitton-Fry, R.M., Grech, A., and Steitz, J.A. (2006) Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22. RNA 12:872-882.
• Cook, H.L., Lytle, J.R., Mischo, H.E., Li, M-J, Rossi, J.J., Silva, D.P., Desrosiers, R.C., and Steitz, J.A. (2005) Small nuclear RNAs encoded by Herpesvirus saimiri upregulate the expression of genes linked to T cell activation in virally transformed T cells. Curr. Biol.  15:974–979.
• Conrad, N.K. and Steitz, J.A. (2005) A Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts. EMBO J. 10:1831-1841.

Thomas Steitz

• Kamtekar, S., Ho, R.S., Cocco, M.J., Li, W., Wenwieser, S.V., Boocock, M.R., Grindley, N.D., and Steitz, T.A. (2006) Implications of structures of synaptic tetramers of gamma/delta resolvase for the mechanism of recombination. Proc. Natl. Acad. Sci. USA 103:10642-10647.
• Kamtekar, S., Berman, A.J., Wang, J., Lazaro, J.M., de Vega, M., Blanco, L., Salas, M., and Steitz, T.A. (2006) The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. EMBO J. 25:1335-1343.
• Li, W., Kamtekar, S., Xiong, Y., Sarkis, G.J., Grindley, N.D., and Steitz, T.A. (2005) Structure of a synaptic gamma/delta resolvase tetramer covalently linked to two cleaved DNAs. Science 309:1210-1215.
• Kamtekar, S., Berman, A.J., Wang, J., Lazaro, J.M., de Vega, M., Blanco, L., Salas, M., and Steitz, T.A. (2004) Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophase phi29. Mol. Cell. 16:609-618. (Erratum: Mol. Cell. 16:1035-1036.)
• Pata, J.D., Stirtan, W.G., Goldstein, S.W., and Steitz, T.A. (2004) Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. Proc. Natl. Acad. Sci. USA 101:10548-10553.

Peter Tattersall

• Ruiz, Z., D'Abramo, A.M., Jr., and Tattersall, P. (2006) Differential roles for the C-terminal hexapeptide domains of NS2 splice variants during MVM infection of murine cells. Virology 349:382-395.
• Farr, G., Cotmore, S.F., and Tattersall, P. (2006) VP2 cleavage and the leucine ring at the base of the fivefold cylinder control pH-dependent externalization of both the VP1 N-terminus and the genome of Minute Virus of Mice. J. Virol. 80:161-171.
• Cotmore, S.F. and Tattersall, P. (2005) Parvoviruses, Chapter 29, in: DNA Replication in Eukaryotic Cells (2nd edition), DePamphilis, M.L., ed., CSHL Press, London, in press.
• Farr, G., Zhang, L-G., and Tattersall, P. (2005) Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry. Proc. Natl. Acad. Sci. USA 102:17148-17153.
• Cotmore, S.F. and Tattersall, P. (2005) Genome structure and organisation, Chapter 7, in: The Parvoviruses, Kerr, J., Cotmore, S.F., Bloom, M.E., Linden, R.M., and Parrish, C.R., eds., Hodder Arnold, London,  pp. 73-94.
• Cotmore, S.F. and Tattersall, P. (2005) A rolling hairpin strategy: basic mechanisms of DNA replication in the parvoviruses, Chapter 14, in: The Parvoviruses, Kerr, J., Cotmore, S.F., Bloom, M.E., Linden, R.M., and Parrish, C.R., eds., Hodder Arnold, London, pp. 171-188.

Paul Turner

• Dennehy, J.J., Friedenberg, N.A., Holt, R.D., and Turner, P.E. (2006) Viral ecology and the maintenance of novel host use. Am. Nat. 167:429-439.
• Dennehy, J.J., Friedenberg, N.A., Yang, Y.W., and Turner, P.E. (2006) Bacteriophage migration via nematode vectors: host-parasite-consumer interactions in laboratory microcosms. Appl. Environ. Microbiol. 72:1974-1979.
• Duffy, S., Turner, P.E., and Burch, C.L. (2006) Pleiotropic costs of niche expansion in the RNA bacteriophage phi 6. Genetics 172:751-757.
• Silander, O.K., Weinreich, D.M., Wright, K.M., O’Keefe, K.J., Rang, C.U., Turner, P.E., and Chao, L. (2005) Widespread genetic exchange among terrestrial bacteriophages. Proc. Natl. Acad. Sci. USA 102:19009-19014.
• Montville, R., Froissart, R., Remold, S.K., Tenaillon, O., and Turner, P.E. (2005) Evolution of mutational robustness in an RNA virus. PloS Biol. 3:e381.
• Dennehy, J.J. and Turner, P.E. (2004) Reduced fecundity is the cost of cheating in RNA virus phi6. Proc. Biol. Sci. 271:2275-2282.

Anthony Van den Pol

• Wollmann, G., Robek, M.D., and Van den Pol, A.N. (2007) Variable deficiencies in the interferon response enhance susceptibility to VSV oncolytic actions in glioblastoma but not in normal human glia. J. Virol. 81:1479-1491.
• Van den Pol, A.N., Robek, M.D., Ghosh, P.K., Ozduman, K., Bandi, P., Whim, M.D., and Wollmann, G. (2006) Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain. J. Virol. 80:332-348.
• Van den Pol, A.N. (2006) Viral infections in the developing and mature brain. Trends Neurosci. 29:398-406.

• Reuter, J.D., Wilson, J.H., Idoko, K.E, and Van den Pol, A.N. (2005) CD4+ T-cell reconstitution reduces cytomegalovirus in the immunocompromised brain. J. Virol. 79:9527-9539.
• Wollmann, G., Tattersall, P., and Van den Pol, A.N. (2005) Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential. J. Virol. 79:6005-6022.
• Van den Pol, A.N., Acuna-Goycolea, C., Clark, K.R., and Ghosh, P.K. (2004) Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 42:635-652.
• Reuter, J.D., Gomez, D.L., Wilson, J.H., and Van den Pol, A.N. (2004) Systemic immune deficiency necessary for cytomegalovirus invasion of the mature brain. J. Virol. 78:1473-1487.

Yong Xiong

• Xiong, Y. and Steitz, T.A. (2006) A story with a good ending: tRNA 3'-end maturation by CCA-adding enzymes. Curr. Opin. Struct. Biol. 16:12-17.
• Li, W., Kamtekar, S., Xiong, Y., Grindley, N.D., and Steitz, T.A. (2005) Structure of a synaptic resolvase tetramer covalently linked to two cleaved DNAs. Science 309:1210-1215.
• Xiong, Y. and Steitz, T.A. (2004) Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template. Nature 430:640-645.
• Xiong, Y., Li, F., Wang, J., Weiner, A.M., and Steitz, T.A. (2003) Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes. Mol. Cell 12:1165-1172.
• Pan, B., Xiong, Y., Shi, K., and Sundaralingam. M. (2003) Crystal structure of a bulged RNA tetraplex at 1.1 Å resolution: Implications for a novel binding site in RNA tetraplexes. Structure 11:1423-1430.