Anna Marie Pyle

William Edward Gilbert Prof of Molecular, Cellular & Developmental Biology; Director, Division of Biological Sciences

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Computational Biology and Bioinformatics | Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Molecular, Cellular, and Developmental BiologyMolecular VirologyStructural BiologyCenter for RNA Science and Medicine, YaleRNA Biology | Structural Biology | Mechanisms of Viral PathogenesisMolecular Virology


Research Interests

Structure and function of catalytic RNA; RNA helicase mechanisms; Computational analysis of RNA structure more...


Selected Publications

  • Dumont, S., et al. (2006). RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature 439:105-108.
  • Solem, A., Zingler, N., and Pyle, A.M. (2006). A DEAD protein that activates intron self-splicing without unwinding RNA. Mol. Cell 24:611-617.
  • Toor, N., Keating, K. S., Taylor, S. D. and Pyle, A. M. Crystal structure of a self-spliced group II intron. Science 320, 77-82 (2008)

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