Laboratory Research at Yale on Human Viral Pathogens

Hepatitis B virus

Dr. Cheng is developing new drugs with anti-HBV activity.

Hepatitis C virus

Dr. Pyle is studying the structure and dynamic behavior of the HCV replication machinery. Dr. Kozal is interested in the evolution of HCV strains. Dr. Lindenbach is studying aspects of in vitro replication of HCV.

Herpes viruses

Drs. Miller and El-Guindy are studying transcriptional regulation by Epstein-Barr Virus and Kaposi's sarcoma herpes virus and the basis for the switch between latent and lytic infection by these viruses. Dr. Joan Steitz is studying the role of small viral RNAs and cell activation in herpes virus replication and transformation. Dr. Cheng is testing the activity of small molecule inhibitors of herpes virus replication. Dr. Iwasaki is characterizing mucosal immunity to herpes virus infection. Dr. Van den Pol is studying the mechanisms of infection and treatment for CMV infections of the central nervous system.


Dr. DiMaio is exploring the role of human papillomavirus oncogenes in maintaining cervical cancer cells and in bypassing senescence, and is studying the process of HPV entry. He is also using the bovine papillomavirus E5 protein as a platform to develop new anti-viral approaches. Dr. Brandsma is studying the replication of the cottontail rabbit papillomavirus. Drs. Yarbrough and Issaeva are studying the pathogenesis of HPV-associated head and neck tumors. Drs. DiMaio, Santin, Iwasaki, and Brandsma are developing new vaccination strategies to prevent and treat papillomavirus infections. These latter studies are carried out in collaboration with colleagues in Immunobiology, Pathology, Comparative Medicine, Microbial Pathogenesis, and Biomedical Engineering.


Dr. Martinello is studying respiratory syncytial virus and human metopneumovirus with emphasis on their role in human disease and the emergence of drug resistance.


Dr. Tattersall is exploring the mechanisms of parvovirus DNA replication and packaging and the use of parvoviruses as vaccines and oncolytic agents. Dr. Tattersall also studies the epidemiology and biology of human bocavirus, a new pathogen.


Dr. Pyle studies proteins critical for transcription of vaccinia virus, which is closely related to variola major, which causes smallpox.


Dr. Mothes is examining the molecular mechanisms of cell entry and virus maturation by retroviruses, including HIV. Dr. Kozal is interested in the evolution of HIV in response to drug treatment. Drs. Xiong and Anderson are studying the biochemistry and structural biology of HIV replication proteins. Dr. Cheng is testing the activity of small molecule inhibitors of HIV replication, and Drs. Glazer and DiMaio are exploring novel methods to block HIV infection. Drs. Glazer, Kumar and DiMaio are exploring novel methods to block HIV infection.


Dr. Rose is studying rhabdovirus replication and developing VSV as a novel vaccine agent against multiple viral pathogens including HIV, papillomavirus, and influenza. Drs. Van den Pol and Tattersall are exploring the use of VSV and other viruses as oncolytic agents.

West Nile virus

Dr. Fikrig is studying the immunology and replication of West Nile virus, and attempting to develop new strategies to inhibit virus replication.